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KMID : 1103720120660040375
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Journal of the Korean Society of Radiology
2012 Volume.66 No. 4 p.375 ~ p.384
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Reversible Restricted Diffusion in the Corpus Callosum in Various Pediatric Diseases
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Kim Won-Kyung
Hong Hyun-Sook
Lee A-Leum
Cha Jang-Gyu
Lee Hae-Kyung
Bae Won-Kyung
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Abstract
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Purpose: To evaluate the reversible restricted diffusion in the corpus callosum in pediatric patients with clinical findings, and to discuss the possible pathogenesis of these lesions.
Materials and Methods : Between 2007 and 2011, seven children with reversible signal abnormalities in the corpus callosum were identified and retrospectively reviewed.
Results: Diseases and conditions associated with lesions included: trauma (n = 3), neonatal seizure (n = 1), clinically suspected mild encephalopathy (n = 1), multiple sclerosis (n = 1), and seizure with subdural hygroma (n = 1). The callosal lesions were located in the splenium and the genu (n = 2), the splenium and the body (n = 1), and the splenium only (n = 4). The shape of the lesions was round-to-ovoid (n = 4) or linear (n = 3). Follow-up MRI scans showed completely resolved (n = 6) or persistent (n = 1) signal abnormalities on diffusion-weighted imaging as well as apparent diffusion coefficient mapping. Clinical outcomes were good in six of the patents but poor in the seventh.
Conclusion: Reversible restricted diffusion in the corpus callosum can develop in various diseases. Knowledge of the MRI findings and associated diseases might be helpful in predicting patients’ conditions and clinical outcomes.
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KEYWORD
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Corpus Callosum, Splenium, Diffusion-Weighted Imaging, Magnetic Resonance Imaging, Diffuse Axonal Injury, Cytotoxic Edema
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